A novel amide alkaloid, (E)-1-(5-hydroxy-6-((3,4,5-trihydroxy-6-(((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-indol-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one, was isolated from Portulaca oleracea L. This compound was named β-D-Glc-oleraindole G. Its structure was elucidated using NMR and HR-ESI-TOF-MS spectra. β-D-Glc-Oleraindole G displayed anti-inflammatory activity at 20 μM. © 2022, Springer Science+Business Media, LLC, part of Springer Nature.