Diterpenoid Alkaloids from the Roots of Aconitum rockii and Their Antifeedant Activity

Chinese Journal of Organic Chemistry
2022.0

Abstract

As part of our ongoing research program toward discovering structurally intriguing and biologically important diterpenoid alkaloids from the Aconitum genera, four new diterpenoid alkaloids, including three C-19-diterpenoid alkaloids (rockidines A similar to C) and one C-20-diterpenoid alkaloid (rockisine A) were isolated from the roots of Aconitum rockii Fletcher et Lauener in this paper. Their structures were elucidated on the basis of spectroscopic analyses (HR-ESI-MS, NMR and IR). All the new compounds 1 similar to 4, alone with ten known compounds 5 similar to 14 isolated in our previous work, were evaluated for their antifeedant activities, and compound 13 showed highly potent antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 0.13 mg/cm(2).

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