Uncommon Bis‐quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis

Chinese Journal of Chemistry
2021.0

Abstract

Two new bis-quinolizidine alkaloids, neopetrosiasins A (1) and B (2), possessing cis- and trans-quinolizidine nuclei, one known related analogue petrosin (3) and three known xestospongins (4—6), were isolated from the South China Sea sponge Neopetrosia chaliniformis. The structures of new compounds were unambiguously determined by extensive spectroscopic and single-crystal X-ray analyses. In bioassay, compounds 4—6 exhibited moderate cytotoxicity against several human cancer cells. © 2021 SIOC, CAS, Shanghai and Wiley-VCH GmbH

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