Synthesis of 5α,6-Dihydroveragranines A and B

Organic Letters
2022.0

Abstract

The 5alpha,6-dihydro congeners of veragranines A and B, two steroidal alkaloids with an unprecedented hexacyclic skeleton and potent analgesic effects, were synthesized from hecogenin acetate within six steps. This work enables quick access to the hexacyclic skeleton and is amendable to prepare other D-ring-modified congeners.

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