The genus Fagara (Rutaceae) is close to 250 species that are commonly used in traditional medicine all over the world for treating various disorders. Fagara species have been investigated for their phytochemistry and pharmacological properties. This chapter is aimed at reviewing the antibacterial potential of plants from the genus Fagara against drug-sensitive and drug-resistant phenotypes. Their ethnobotany and phytochemistry are also discussed. The available information on various species belonging to the genus Fagara was collected on websites such as Pubmed, Scopus, Google Scholar, and Web of Science. Alkaloids are the major secondary metabolites isolated in this genus. Moreover, they possess weak to outstanding activities against drug-sensitive and drug-resistant phenotypes. We identified acridone alkaloids canthine-6-one (5), 8- acetonyldihydrochelerythrine (10), 8-oxochelerythrine (11), and 10-methoxycanthin-6-one (12) isolated from F. paracanthum, benzophenanthridines alkaloids, buesgenine (1) isolated in F. tessmannii and avicine (8), and chelerythrine (9) isolated in F. rhoifolium as potential antibacterial agents. The overall data highlight the importance of Fagara species as potential sources of antibacterial agents for the treatment of infections caused by resistant bacteria.