An efficient new approach toward the synthesis of 2-methylperlolidine alkaloids has been illustrated, the present article describes the synthesis, in Antileukemic activities and in-silico molecular docking studies of compound 2-methylperlolidine 4. The synthesis of 4 is initiated by a new, efficient, solvent-free Minisci radical reaction. The structures of the compounds are established using both spectral and analytical data. An in-silico prediction of activity spectra for substances, the Swiss ADME-assisted docking approach is found to be suitable to derive and synthesize effective receptor tyrosine kinase agents. Claisen ester condensation reaction resulted in the discovery of inexpensive and user-friendly solvents. Structures of the newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, and HRMS (FTMS + PESI) analyses. Molecular docking was investigated to determine the probable binding mode. The experimental values and docking simulation exhibited that the complex had better anti-leukemic than the positive reference 2-methylperlolidine. © 2023 Connect Journals