Влияние зонгорина на активность АТФ-зависимых K<sup><b>+</b></sup>-каналов и состояние мегапоры митохондрий печени крыс

Экспериментальная и клиническая фармакология
2021.0

Abstract

It is established that diterpenoid alkaloid songorine in micromolar concentrations in the presence of ATP, activates like diazoxide and 1-O-benzoylnapelline, the mito KATP-channel (IC50 = 1.0 mu M) and also dose-dependently inhibits opening of the Ca2+ -dependent megapore of isolated rat liver mitochondria (IC50 = 35.2 +/- 3.1 mu M).

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