Functionalization of bioactive substrates with a F5SCH = CH moiety

Journal of Sulfur Chemistry
2020.0

Abstract

A convenient approach to modify bioactive substrates such as daunorubicin, cytisine, and camphecene with a pentafluorosulfanylvinyl moiety have been suggested. F5S-CH = CH derivatives of daunorubicin were obtained by acylation with reactive 4-nitrophenyl-4-(pentafluoro-lambda(6)-sulfanyl)alkenyl carbonates, while the corresponding conjugates of anthracycline antibiotic daunorubicin, alkaloid cytisine and camphecene were synthesized using a click chemistry procedure.

Knowledge Graph

Similar Paper

Functionalization of bioactive substrates with a F<sub>5</sub>SCH = CH moiety
Journal of Sulfur Chemistry 2020.0
Synthesis of 3′-azido-3′-deoxythymidine (AZT)—Cinchona alkaloid conjugates via click chemistry: Toward novel fluorescent markers and cytostatic agents
Bioorganic &amp; Medicinal Chemistry Letters 2011.0
Synthesis of daunorubicin analogs with novel 9-acyl substituents
Journal of Medicinal Chemistry 1979.0
Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors
Bioorganic &amp; Medicinal Chemistry 2009.0
Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry
ACS Medicinal Chemistry Letters 2014.0
N-(Cyanomethyl)- and N-(2-methoxy-1-cyanoethyl)anthracyclines and related carboxyl derivatives
Journal of Medicinal Chemistry 1986.0
Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S -adenosylhomocysteine hydrolase
Bioorganic &amp; Medicinal Chemistry Letters 2004.0
C5-Modified nucleosides exhibiting anticancer activity
Bioorganic &amp; Medicinal Chemistry Letters 2009.0
Micelles catalyzed chemo- and regio-selective one pot and one step synthesis of 2,3,5,6-tetrakis(alkyl and arylsulfanyl)-1,4-benzoquinones and 2,5-diaminosubstituted-1,4-benzoquinones “In-Water” and their biological evaluation as antibacterial and antifungal agents
European Journal of Medicinal Chemistry 2012.0
Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity
Journal of Medicinal Chemistry 2012.0