Oxidative Fragmentation of Cytisine as an Entry to the Bis(piperidine) Scaffold of Virgidivarine

HETEROCYCLES
2022.0

Abstract

Using virgidivarine as a focus, we have extended the oxidative fragmentation of (-)-cytisine as a source of functionalized heterocyclic fragments to provide a novel bi s(piperidine) 2'-epivirgidivarine. This stereochemically-defined scaffold offers synthetic versatility within an sp(3)-rich environment that makes it amenable to further manipulation and development within the context of de novo drug design.

Knowledge Graph

Similar Paper