Exploration for specialized metabolites of Okinawan marine spongesAgelasspp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2), 9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (5). Their structures were elucidated on the basis of spectroscopic analyses. Agesasines A (1) and B (2) were assigned as rare bromopyrrole alkaloids lacking an aminoimidazole moiety, while3-5were elucidated to be linear bromopyrrole alkaloids with either aminoimidazolone, aminoimidazole, orN-methylated aminoimidazole moieties.