Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122

Organic Letters
2022.0

Abstract

Chevalinulins A (1)andB(2), two indolediketopiperazine alkaloids containing an unprecedented spiro-[bicyclo[2.2.2]octane-diketopiperazine] skeleton, together with aknown analogue neoechinulin B (3), were isolated from the deep-sea cold-seep-derived fungusAspergillus chevalieriCS-122. Theirstructures were determined by spectroscopic analysis, single-crystalX-ray diffraction, specific rotation (SR), and NMR calculations.Compounds1and2exhibited significantin vivoproangiogenicactivity in transgenic zebrafish.

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