Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids

Chemistry Letters
2021.0

Abstract

This highlight review describes the syntheses of 2-azabicyclo- [3.3.1]nonanes, focusing on synthetic studies of the macrocyclic diamine alkaloids, sarain A and madangamines. These alkaloids have a 2-azabicyclo[3.3.1]nonane that is fused with an N-heterocycle. Researchers employed unique strategies to construct different structures with additional substituents and functional groups in the target molecule. © 2021 The Chemical Society of Japan.

DOI： 10.1246/CL.200695

Knowledge Graph

Similar Paper

Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids
Chemistry Letters 2021.0
Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids
Chemistry Letters 2021.0
The Alkaloids of the Madangamine Group
The Alkaloids: Chemistry and Biology 2015.0
Synthesis of 2‐Azabicyclo[m.n.0]–Alkanes and Their Application towards the Synthesis of Strychnos and Stemona Classes of Alkaloids
European Journal of Organic Chemistry 2020.0
Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids
Nature Communications 2022.0
Pyrrolizidine alkaloid analogues. Synthesis of 10-membered macrocyclic diesters of (±)-synthanecine A. X-Ray molecular structure of (±)-6,7-O,O-(succinyl)synthanecine A
J. Chem. Soc., Perkin Trans. 1 2004.0
Asymmetric Total Syntheses of Macroline-Type Alkaloids Alstomicine and Alstofolinine A
Synthesis 2023.0
Further studies of alkaloids from Reniera sarai: Structures of saraine-3 and isosaraine-3; absolute stereochemistry of saraine-1 and saraine-2
Tetrahedron 1996.0
Total Synthesis of Vinorine
Organic Letters 2023.0
Pyrrolizidine alkaloid analogues. Synthesis of 11-membered macrocyclic diesters of (±)-synthanecine A
J. Chem. Soc., Perkin Trans. 1 2004.0