Oral diseases are common health problems worldwide. There is a global need for the alternative, safe, and effective treatment for oral diseases. Compounds from medicinal plants have been proven to be an effective alternative. To screen the anticariogenic activity, organic solvents (hexane, ethyl acetate, methanol) and aqueous extracts of 19 medicinal plant seeds and fruits were assayed against five different cariogenic bacteria by agar well diffusion assay and MIC. ethyl acetate (E), methanol (M) and aqueous extract of Quercus infecteria exhibited significant growth inhibition in all the selected cariogenic bacteria, which is comparable with the standard antibiotic drug erythromycine. The MIC values of 78, 625, and 156 μg/mL were obtained against L. casei when Q. infectoria (E), P. granatum (E), and Q. infectoria (M) extracts were used. Ethyl acetate and methanolic extract of Q. infectoria contains tannins, cardiac glycosides, steroids, terpenoids, phenolic compounds, and alkaloids. Bioactive compounds from all the effective crude extracts were separated using TLC and localized bioautographically. Ethyl acetate and methanolic extract of Q. infectoria were found to be useful for clinical evaluation and development of potential alternatives for the treatment against cariogenic bacteria responsible for dental caries. © 2020 Scrivener Publishing LLC. All rights reserved.