Synthesis and antiviral activity of lycorine derivatives

Journal of Asian Natural Products Research
2020.0

Abstract

There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives 7c-m with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative 7e enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Knowledge Graph

Similar Paper