The objective of the present research investigation was to protect Bombax ceiba by revealing their endophytic fungi diversity for disease management. In the present research investigation, a total of 64 fungal endophytes were purified and, Aspergillus tamari was identified as a core fungal endophyte. The fungus showed the highest average linear growth rate of 6.2 mm/day and isolation frequency at 80% on tomato dextrose agar with white or dark brown or black or purple -brown to yellowish-green color variations with mycelial growth in between 65 mm to 90 mm on the media and 8 to 31 numbers of spores/microscopic field. Further, the fungus revealed 2.86 g/100g of total wet biomass and 0.25 g/100g of the dried biomass of corn bran with 5.30 g/100ml of the aqueous crude extract in solid-state fermentation. Mycochemical screening of the crude extract showed alkaloids, terpenoids, steroids, tannins, saponins, flavonoids, phenols with 29.0060 +/- 0.03223 mg of total phenolic and 12.2549 +/- 0.02345 mg of flavonoids content. Thin layer chromatography was used to get purified potent spots of alkaloids [0.29], flavonoids [0.41] terpenoids [0.15] and saponins [0.91]. The fungus produced chitinase, amylase, protease, and cellulases enzyme. Further the aqueous crude extract worked as an agent of antioxidant in the FRAP at the rate of 1.2407 +/- 0.00702 while PM at 0.7983 +/- 0.00351, antimicrobials against E. coli (100mg/ml at the rate of 16.3 +/- 0.57) and Aspergillus niger (100mg/ml at the rate of 20.5 +/- 0.24), and in anthelmintic activity, extract induced paralysis in earthworms within 3 minutes and death in 8 minutes. It is concluded that the Bombax ceiba has the potential to purify the potent fungal endophytes and their bioactive compounds that may be helpful to evaluate in vivo models against different diseases.