Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005

Bioorganic & Medicinal Chemistry Letters
2015.0

Abstract

During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of 1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of 1 was determined by ROESY and advanced Marfey's method. © 2015 Elsevier Ltd. All rights reserved.

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