Serralongamines B–D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum , and their inhibitory effects on foam cell formation in macrophages

Bioorganic & Medicinal Chemistry Letters
2016.0

Abstract

Three new Lycopodium alkaloids, serralongamines B-D (1-3), have been isolated from the club moss Lycopodium serratum var. longipetiolatum, and the structures were elucidated on the basis of spectroscopic data and chemical transformation. 1 and 3 significantly exhibited the inhibitory activity against foam cell formation in human macrophages, one of characteristic features of early atherosclerotic lesions. CI - Copyright (c) 2016. Published by Elsevier Ltd.

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