A novel sesquiterpene, nordine (or 2,2,9-trimethyl-5-methylene-12-oxa-bicyclo[6.3.1] dodecane-4,9-diol) (1) and two new copyrine alkaloids of eupolauridine skeleton, viz., 4,11-dimethoxyeupolauridine (2) and 2-methoxy-3-hydroxyeupolauridine (3), along with five alkaloidal (4-8) and nine non-alkaloidal compounds (9-17), have been isolated from the bark and roots of Anaxagorea javanica Blume. The structures of the new constituents were deduced by NMR spectral data. Compounds 6 and 7 displayed moderate inhibition of NO production with IC50 values of 18.2 and 32.3 mu g/ml respectively. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.