Rapid Construction of the [6‐6‐6‐5] Tetracyclic Skeleton of the Daphniphyllum Alkaloid Daphenylline

Chemistry – An Asian Journal
2012.0

Abstract

You can call me Al: A concise route for construction of the [6-6-6-5] tetracyclic skeleton of daphenylline, a structurally novel Daphniphyllum alkaloid, has been developed with full stereocontrol in only 8 steps from two known fragments. This approach features an intramolecular [3+2] cycloaddition of a 2-azaallyl anion with an alkene to form the cis-fused AC rings. CI - Copyright (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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