Isolation and cytotoxic investigation of new carbazole alkaloids from Murraya koenigii (Linn.) Spreng

Tetrahedron

2015.0

Abstract

Six new carbazole alkaloids, murrastanine-A (1), murrastinine-A, -B, -C (2-4), murrayatanine-A (5) and bismahanimboline (6), were isolated from the bark and leaves of Murraya koenigli (Linn.) Spreng along with 24 known carbazole alkaloids. The structure of these compounds were elucidated by extensive spectroscopic analysis. Murrastinine-C (4) and murrayatanine-A (5) exhibited cytotoxic activity against HL-60 and HeLa (CD50<20 mu g/mL) via MTT assay. (C) 2015 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tet.2015.04.037

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