Naphthoquinone–Oxindole Alkaloids, Coprisidins A and B, from a Gut-Associated Bacterium in the Dung Beetle, Copris tripartitus

Organic Letters
2016.0

Abstract

Coprisidins A and B (1 and 2) were isolated from a gut -associated Streptomyces sp. in the dung beetle Copris tripartitus. Using a combination of spectroscopic techniques, the structures of the compounds were determined to be the first examples of natural naphthoquinone oxindole alkaloids. Coprisidin A was found to inhibit the action of Na+/K+-ATPase, and coprisidin B showed activity for the induction of NAD(P)H:quinone oxidoreductase 1.

Knowledge Graph

Similar Paper

Naphthoquinone–Oxindole Alkaloids, Coprisidins A and B, from a Gut-Associated Bacterium in the Dung Beetle, Copris tripartitus
Organic Letters 2016.0
Naphthoquinone–Oxindole Alkaloids, Coprisidins A and B, from a Gut-Associated Bacterium in the Dung Beetle, <i>Copris tripartitus</i>
Organic Letters 2016.0
Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
Bioorganic &amp; Medicinal Chemistry Letters 2011.0
Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
Bioorganic &amp; Medicinal Chemistry Letters 2011.0
Camporidines A and B: Antimetastatic and Anti-inflammatory Polyketide Alkaloids from a Gut Bacterium of <i>Camponotus kiusiuensis</i>
Journal of Natural Products 2019.0
Polyketide Origin of the Indole Ring during the Biosynthesis of Indole Alkaloid Coprisidins
Organic Letters 2024.0
Leuconoxine, Kopsinitarine, Kopsijasmine, and Kopsinone Derivatives from Kopsia
Journal of Natural Products 2007.0
Leuconoxine, Kopsinitarine, Kopsijasmine, and Kopsinone Derivatives from <i>Kopsia</i>
Journal of Natural Products 2007.0
Camporidines A and B: Antimetastatic and Anti-inflammatory Polyketide Alkaloids from a Gut Bacterium of <i>Camponotus kiusiuensis</i>
Journal of Natural Products 2019.0
Structures and Biosynthetic Pathway of Coprisamides C and D, 2-Alkenylcinnamic Acid-Containing Peptides from the Gut Bacterium of the Carrion Beetle <i>Silpha perforata</i>
Journal of Natural Products 2021.0