Four new prenylated indole alkaloids (1-4), and four new chromone derivatives (7-10), together with six known compounds (5, 6, and 11-14), have been isolated from the mangrove sediment derived fungus Penicillium sp. SCSI0041218, cultured in the 1% NaCI PDB substrate. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configuration of the prenylated indole alkaloids were elucidated based on the comparison of ECDs with known analogues. The absolute configurations of the chromone derivatives were determined by time-dependent density functional theory calculations of the ECD spectra. In all of these isolated compounds, penixanthones A and B (12 and 13) exhibited antiallergic activities in vitro. (C) 2017 Elsevier Ltd. All rights reserved.