Thalicfoetine, a novel isoquinoline alkaloid with antibacterial activity from Thalictrum foetidum

Tetrahedron Letters
2019.0

Abstract

Thalicfoetine (1), the first O-bridged spirobenzylisoquinoline alkaloid possesses a spiro tetrahydropyridine-furanone core, was isolated from the roots of Thalictrum foetidum. Its structure was elucidated by extensive spectroscopic analyses and ECD calculation. Moreover, 1 exhibited antibacterial activity against Bacillus subtilis significantly with MIC value of 3.12 μg/mL. © 2019 Elsevier Ltd

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