Bousigonine A and B, bis- and tri-indole alkaloids from Bousigonia mekongensis and their preventing high glucose-induced podocyte injury activity

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2019.0

Abstract

Bousigonine A (1), an unprecedented eburnamine-voaphylline type dimeric indole alkaloid, and Bousigonine B (2), the first example of eburnamine-eburnamine-aspidospermine type trimeric indole alkaloid were isolated from Bousigonia mekongensis. Their structures were elucidated mainly by spectroscopic analysis and compared to published data. Their preventing high glucose-induced podocyte injury activity were evaluated for the first time, and compound I exhibited significant effect with EC50 value of 2.5 mu M. (C) 2019 Published by Elsevier Ltd.

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