Three new dibromopyrrole alkaloids from the South China Sea sponge Agelas nemoechinata

Tetrahedron Letters
2019.0

Abstract

Three new dibromopyrrole alkaloids, 9-N-methylcylindradine A (1), 1-N-methylugibohlin (2), nemoechine H (3), together with one known dibromopyrrole alkaloid N-methyldibromoisophakellin (4) were isolated from the South China Sea sponge Agelas nemoechinata. Their structures were elucidated by comprehensive spectroscopic methods including HRESIMS and NMR, and the absolute configuration of compound 1 was further confirmed by comparison of optical rotation. Compound 3 exhibited moderate cytotoxic activity against K562 and L-02 with IC50 values of 6.1 μM and 12.3 μM, respectively. © 2019 Elsevier Ltd

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