Chrotacumines G–J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity

Bioorganic & Medicinal Chemistry Letters
2014.0

Abstract

Four new chromone alkaloids, chrotacumines G-J (1-4), have been isolated from the barks of Dysoxylum acutangulum. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Chrotacumines G and J (1 and 4) showed osteoclast differentiation inhibitory activity in a dose dependent manner. © 2014 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.bmcl.2014.04.020

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