Two novel indole alkaloids and new quinazoline alkaloids, namely leucomidines A-C (1-3), were isolated from the barks of Leuconotis griffithii. The structures including the absolute configuration were elucidated on the basis of spectroscopic data, chemical means, and CD calculations. The quinazoline alkaloid, 3, is proposed to be derived from the same biogenetic precursor as the indole alkaloids 1 and 2. (C) 2012 Elsevier Ltd. All rights reserved.