Two new bis-alkaloids, flavifloramides A (1) and B (2), as well as two known alkaloids, N-trans-feruloyltyramine (3) and paprazine (4), were isolated from the aerial part of Piper flaviflorum. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.