First Total Synthesis of the 2,7‐Naphthyridine Alkaloids Lophocladine A and B

Archiv der Pharmazie
2006.0

Abstract

The one-pot reaction of 4-benzylpyridine-3-carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.

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