Two novel steroidal alkaloid glycosides, lycioside A (1) and lycioside B (2) were isolated from the seeds of Lycium barbarum. Their structures were determined by various spectroscopic analyses. Compounds 1 and 2 showed inhibitory activities with the IC 50 values of 75.3 and 72.8Î?M against rat intestinal sucrase, and 63.4 and 59.1Î?M against rat intestinal maltase. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.