Henrycinols A (1) and B (2), two novel indole alkaloids, together with three known compounds, (+)-Delta(14)-vincamine (3), (+)-16-epi-Delta(14)-vincamine (4), and (+)-isoeburnamine (5), were isolated from the roots of Melodinus henryi CRAIB. Their structures were established on the basis of 1D- and 2D-NMR spectroscopic analysis. The relative configuration of henrycinols A and B was determined by NOESY analysis.