Three new macrocyclic beta-dihydroagarofuran-type sesquiterpene pyridine alkaloids, fortuneines A (1), B (2), and C (3), together with the four known alkaloids wilfornine E (4), aquifoliunine E-I (5), euoverrine B (6), and euojaponine I(7), were isolated from the aerial parts of Euonymus fortunei. Their structures were elucidated by spectroscopic methods, including HR-ESI-MS, (1)H- and (13)C-NMR, DEPT, (1)H,(1)H-COSY, HSQC, HMBC, and ROESY. This is the first isolation of the above sesquiterpene pyridine alkaloids from this plant, except for compound 6.