Natural product chemistry, 140. Synthesis of some new acridones

Liebigs Annalen der Chemie
1990.0

Abstract

Methyl 6‐amino‐2,3‐dimethoxybenzoate (6) which was obtained from 6‐formyl‐2,3‐dimethoxybenzoic acid (1), was treated with phloroglucinol to give two new acridone alkaloids, 1,3,8‐trihydroxy‐7‐methoxy‐9‐acridone (7) and 1,3‐dihydroxy‐7,8‐dimethoxy‐9‐acridone (8). Methylation of 7 and 8 gave another four new acridone alkaloids, 1,8‐dihydroxy‐3,7‐dimethoxy‐9‐acridone (9), 1,8‐dihydroxy‐3,7‐dimethoxy‐10‐methyl‐9‐acridone (10), 1‐hydroxy‐3,7,8‐trimethoxy‐10‐methyl‐9‐acridone (11) and 1,3,7,8‐tetramethoxy‐10‐methyl‐9‐acridone (12). Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

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