N, N‐Dimethyl‐3,4‐dimethoxyphenethylamine has been isolated for the first time as a natural product from Echinocereus merkeri Hildm. N‐Methyl‐3,4‐dimethoxyphenethylamine, 3,4‐dimethoxyphenethylamine, 3‐methoxytyramine, and hordenine were also identified in this species together with the tetrahydroiso‐quinoline alkaloid salsoline. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company