A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis

Phytotherapy Research
2010.0

Abstract

A new protoberberine alkaloid, 3-hydroxy-2-methoxy-9,10-methylenedioxy-8-oxo-protoberberine, along with three known compounds, was isolated from Rhizoma Coptidis. The new compound displayed weak antispasmodic activity against acetylcholine-induced contraction in isolated guinea-pig ileum with an IC50 of 83.7 microm. CI - Copyright 2010 John Wiley & Sons, Ltd.

DOI： 10.1002/ptr.3154

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