Characterization of metabolites in plant extracts ofAncistrocladus likoko by high-performance liquid chromatography coupled on-line with1H NMR spectroscopy

Magnetic Resonance in Chemistry
1999.0

Abstract

One-and two-dimensional stop-flow HPLC-NMR experiments were applied to investigate a root extract of Ancistrocladus likoko (Ancistrocladaceae). Three new naphthylisoquinoline alkaloids with a 5,8′ coupling pattern were found. The constitutions and relative configurations were elucidated by application of H,H-TOCSY and ROESY experiments carried out in the stop-flow mode. This example demonstrates the potential of HPLC-NMR as an efficient coupling technique for plant screening studies in phytochemical analysis. Copyright © 1999 John Wiley & Sons, Ltd.

DOI： 10.1002/(sici)1097-458x(199902)37:2<98::aid-mrc428>3.0.co;2-i

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