A new 6a,7-dehydroaporphine alkaloid, N-acetyldehydroanonaine and a new 2-quinolone alkaloid, simulansine (2), together with 21 known compounds were isolated from the root bark of Zanthoxylum simulans. Their structures were established on the basis of spectral and chemical evidence. Copyright © 1996 Published by Elsevier Science Ltd. All rights reserved.