Three new water-soluble alkaloids (1-3) together with twelve known compounds (4-15) have been isolated from the water extract of leaves of Suregada glomerulata. Their structures were determined by spectroscopic analysis and chemical method. Compounds 1-3 were evaluated for their in vitro inhibitory activity against a-glucosidase and HIV-1 replication. However, no significant activities were found. (C) 2010 Elsevier B.V. All rights reserved.