Three new spermidine alkaloids capparispine (1), capparispine 26-O-beta-D-glucoside (2) and cadabicine 26-O-beta-D-glucoside hydrochloride (3) were isolated from the roots of Capparis spinosa. Their structures were established on the basis of spectroscopic analysis, including 1D and 2D NMR experiments (H-1-H-1 COSY, HSQC, HMBC). (C) 2008 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.