Biomimetic oxidative transformations of pericine: partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia

Tetrahedron Letters
2006.0

Abstract

A new pentacyclic indole alkaloid of the pericine-type, valparicine, representing the first member of this sub-group, was obtained from a Malayan Kopsia species and the structure was established by spectroscopic analysis. A partial synthesis of valparicine and apparicine from pericine was carried out via the Potier-Polonovski reaction and the biogenetic implications are discussed. © 2006 Elsevier Ltd. All rights reserved.

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