Literature

Abstract

Stereoselective synthesis of the CD-ring structure of cortistatin A (1), a novel anti-angiogenic steroidal alkaloid from Indonesian marine sponge, was achieved. The stereogenic tertiary carbon center bearing the isoquinoline moiety was constructed by 1,3-chiral transfer method using Johnson-Claisen rearrangement of the chiral allylic alcohol 5. Subsequent intramolecular Michael-aldol reaction afforded the targeted trans-hydrindane skeleton with moderate stereoselectivity. © 2008 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2008.09.157

Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge

Tetrahedron Letters 2008.0

Stereoselective Synthesis of Core Structure of Cortistatin A

Organic Letters 2011.0

Creation of Readily Accessible and Orally Active Analogue of Cortistatin A

ACS Medicinal Chemistry Letters 2012.0

Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex

Tetrahedron Letters 2007.0

Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex

Tetrahedron Letters 2007.0

Construction of key building blocks towards the synthesis of cortistatins