Total synthesis of (+)-epiquinamide from d-mannitol

Tetrahedron Letters
2009.0

Abstract

The total synthesis of (+)-epiquinamide, a novel quinolizidine alkaloid isolated from the Ecuadoran poison frog, Epipedobates tricolor is described. The key step includes a ring-closing metathesis reaction to construct both the six member rings. d-Mannitol was used as a chiral pool material. © 2008 Elsevier Ltd. All rights reserved.

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