Spermine alkaloids from Albizia adinocephala with activity against Plasmodium falciparum plasmepsin II

Phytochemistry
2002.0

Abstract

Crude MeOH extracts from the stem bark and leaves of a Panamanian specimen of Albizia adinocephala (Leguminosae) were found to inhibit the malarial enzyme plasmepsin II. Bioassay guided fractionation led to the isolation of two new bioactive spermine alkaloids, budmunchiamines L4 and L5.

DOI： 10.1016/s0031-9422(02)00081-x

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