Three novel pteridine alkaloids, pseudoanchynazines A-C (1-3) have been isolated from the sponge Clathria sp. collected by trawling (-100m) in a commercial clam fishery near the coasts of Rio Negro, Argentina, and their structures determined by a combination of chemical and spectroscopic techniques, with emphasis in 2D NMR and tandem mass spectrometry. Compounds 1-3 have two pteridine units and a tryptophan core with a methyl carbamate substituent. © 2002 Published by Elsevier Science Ltd.