First total synthesis of fungerin an antifungal alkaloid from Fusarium sp.
Tetrahedron Letters
1998.0
Abstract
The first total synthesis of fungerin 1, a new antifungal alkaloid, is described. Starting from a 4,5-diiodoimidazole derivative, the procedure involves regioselective prenylation and Heck type reaction steps to give 1 in high yield.