Pibocin B, the First N-O-Methylindole Marine Alkaloid, a Metabolite from the Far-Eastern Ascidian Eudistoma Species

Journal of Natural Products
2001.0

Abstract

Pibocin B (2), the first representative of marine alkaloids with a unique structural feature, an N-O-methylindole group, was isolated from the Far-Eastern ascidian Eudistoma sp. Its structure has been established as (8 beta)-2-bromo-N-O-methyl-6,8-dimethylergoline on the basis of NMR data, FAB and MALDI-TOF MS, and chemical correlations. Pibocin B showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells.

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