In addition to the previously reported (+)-araguspongine A, (+)-araguspongine C, (+)-araguspongine D, (-)-araguspongine E, and (+)-xestospongin 13, two new N-oxide araguspongines, (+)-araguspongine K and (+)-araguspongine L, are described here. Their structures were established on the basis of spectral analyses including H-1-N-15 HMBC. The promising in vitro antimalarial and antituberculosis activities of araguspongine C are reported.