A phytochemical investigation of the chloroform extract of the stem bark of Strychnos soubrensis Hutch. et Dalz. (Loganiaceae) resulted in the isolation of four alkaloids. Three of them were identified as strychnobrasiline, strychnofendlerine, and isosplendine. The fourth one is a new alkaloid for which we propose the structure 14-β-hydroxy-strychnobtasiline. © 1983, American Chemical Society. All rights reserved.