Two new diterpenoid alkaloids, vakhmatine [1] and vakhmadine [2}, have been isolated from Aconitum pa/matum, together with the known alkaloids atisine and hetisine. The structures of 1 and 2 were established by 2D nmr and nOe studies of their acetyl derivatives 4 and 8. © 1991, American Chemical Society. All rights reserved.