[GRAPHICS]A highly stereoselective route to (+)-amphorogynine A, a novel pyrrolizidine recently isolated from the New Caledonian plant Amphorogynine spicata, has been realized. The key step in the approach is a diastereoselective [2 + 2] dichloroketene-chiral enol ether cycloaddition (dr greater than or equal to 93:7) to access a clichlorocyclobutanone intermediate, which is converted into the alkaloid natural product via a pyrrolidinone derivative.